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A potential new weight-loss drug developed by scientists can help people reduce weight whilst keeping them off, researchers say.

Within the study, obese mice addressed with the drug ate less, dropped excess weight and experienced improved metabolic health, like reduced insulin resistance, in comparison with obese mice not because of the drug.

The drug appears to work by enhancing the body's sensitivity to leptin, a hormone that suppresses appetite. It's believed that obese people become desensitized to leptin, meaning their bodies usually do not react to it.

Also help maintain it," said study researcher George Kunos, of the National Institute on Alcohol Abuse and Alcoholism, although "By sensitizing the body to naturally occurring leptin, the new drug could not only promote weight loss.

It's not clear whether the effects will translate to people, because the study was conducted in mice. If it passes a safety test required by the National Institutes of Health, Kunos said, the researchers plan to start tests of the drug in people.